INVESTIGATION OF CYCLODEXTRIN BASED NANOSPONGES
COMPLEXES WITH ANGIOTENSIN I CONVERTING ENZYME
INHIBITORS (ENALAPRIL, CAPTOPRIL, CILAZAPRIL)
ANDREEA ALEXANDRA OLTEANU1, CORINA-CRISTINA ARAMĂ1*, CORALIA BLEOTU2, DUMITRU LUPULEASA3, CRINA MARIA MONCIU1
1“Carol Davila” University of Medicine and Pharmacy Bucharest, Faculty of Pharmacy, Department of Analytical
Chemistry, 6th Traian Vuia st., Bucharest, 020956, Romania
2”Stefan S. Nicolau” Institute of Virology, Cellular and Molecular Pathology Department, 285 Mihai Bravu, Bucharest,
030304, Romania
3“Carol Davila” University of Medicine and Pharmacy Bucharest, Faculty of Pharmacy, Department of Pharmaceutical
Technology and Biopharmaceutics, 6th Traian Vuia st., Bucharest, 020956, Romania
*corresponding author: corina.arama@umf.ro
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Abstract:
Cyclodextrin based nanosponges are cross-linked polymeric networks formed by cyclodextrins and cyclodextrin derivatives;
they are obtained by reacting cyclodextrin with a cross-linker agent such as carbonyldiimidazole, organic carbonates or (±)
epichlorohydrin) and have many important applications as drug delivery systems or for pollutants removal in environmental
issues. Several β-CD, sulfobutylether-β-CD and hydroxypropyl-β-CD nanosponges were prepared using epichlorohydrin as
cross-linker. After liophylization, the polymers were purified and characterized by FT-IR and 1H NMR, respectively. The
complexing properties of the CD polymers were investigated against enalapril, captopril and cilazapril (effective drugs for
controling blood pressure, congestive heart failure, and prevention of stroke and hypertension acting as angiotensin
converting enzyme -ACE- inhibitors), in order to improve their stability and bioavailability and to overcome the possible
drug-excipient interactions. The drug-nanosponge complexes prepared through liophylization were characterized by FT-IR
and 1HNMR; the phase-solubility diagrams, the solubility profile and the loading capacity of the cyclodextrin polymers were
also determined.
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