PERSPECTIVES IN THE EXPERIMENTAL STUDY OF THE
METABOLIC SYNDROME
STELIANA GHIBU1, IOANA ILIE2*, ADRIANA MUREȘAN3, CRISTINA MOGOȘAN1
“Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
1Department of Pharmacology, Physiology and Physiopathology; Faculty of Pharmacy
2Department of Endocrinology, Faculty of Medicine
3Department of Physiology, Faculty of Medicine
*corresponding author: farmacologiecj@yahoo.com, ioanamanaila@yahoo.com
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Abstract:
The metabolic syndrome (MetS) is characterized by alterations of the glucose and lipid metabolism with long-lasting effects
on the individual’s health state. Research animal models resembling the human MetS symptomatology have been designed
throughout time in order to better understand and treat it. Currently, both the genetic animal model and the diet animal model
can be used. The research animal models provide the advantage of a homogenous study which is able to more easily
underline and quantify the consequences of the variation of several parameters such as: diet, obesity, hypertension, insulin
resistance etc. This review presents the main experimental animal models that can be used in the study of MetS.The metabolic syndrome (MetS) is characterized by alterations of the glucose and lipid metabolism with long-lasting effects on the individual’s health state. Research animal models resembling the human MetS symptomatology have been designed throughout time in order to better understand and treat it. Currently, both the genetic animal model and the diet animal model can be used. The research animal models provide the advantage of a homogenous study which is able to more easily underline and quantify the consequences of the variation of several parameters such as: diet, obesity, hypertension, insulin resistance etc. This review presents the main experimental animal models that can be used in the study of MetS.

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