NEW ARGININE DERIVATIVES - SYNTHESIS AND BIOLOGICAL
EVALUATION
ANDREEA PÂNZARIU1, IOANA MIRELA VASINCU1, OANA MARIA DRAGOSTIN1, MARIA DRĂGAN2, FRÉDÉRIC BURON3, SYLVAIN ROUTIER3, LENUŢA PROFIRE1*
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy,
16 Universitatii Street, 700115, Iaşi, România
2Department of Drug Industry and Pharmaceutical Biotechnology , Faculty of Pharmacy, “Grigore T. Popa” University of
Medicine and Pharmacy, 16 Universitatii Street, 700115, Iaşi, România
3Institute of Organic and Analytical Chemistry, University of Orléans - Pôle de Chimie, Chartres Street, 45067, Orléans, France
*corresponding author: nprofire@yahoo.com
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Abstract:
A novel series of L-arginine derivates with imine structure (Schiff bases) were synthetized and the structure was confirmed
using spectral methods: infrared (IR), nuclear magnetic resonance (1H-NMR) and high resolution mass spectroscopy (HRMS).
The antioxidant potential was evaluated in vitro using the DPPH and ABTS radical scavenging assays. Most of the
synthesized compounds revealed a better antioxidant activity in comparison with L-arginine. The most active compounds
were the derivatives that have -NO2 (2e, 2g) and di-OH (2k, 2l) as substituents on the aromatic ring.

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