MICROBIOLOGICAL EVALUATION AND PRESERVATIVE
EFFICIENCY OF NEW MANDELIC ACID DERIVATIVES IN
OINTMENTS
CĂTĂLINA DANIELA STAN1, ALINA ŞTEFANACHE2, GABRIELA TĂTĂRÎNGĂ3*, MARIA DRĂGAN1, CRISTINA GABRIELA TUCHILUŞ4
“Grigore T. Popa” University of Medicine and Pharmacy Iaşi, 16 Universităţii Street, 700115, Iaşi, Romania
1Department of Drug Industry and Pharmaceutical Biotechnologies, Faculty of Pharmacy
2Department of General and Inorganic Chemistry, Faculty of Pharmacy
3Department of Organic Chemistry, Faculty of Pharmacy
4Department of Microbiology, Faculty of Medicine
*corresponding author: gtataringa22@yahoo.com
Download Full Article

Abstract:
The aim of this study was to investigate the antibacterial and antifungal activity of oxi-acetyl mandelic acid and oxipropionyl
mandelic acid and also to evaluate the preservative efficiency of these two new mandelic acid derivatives in
ointments. The antimicrobial activity was determined by the agar disk diffusion method and by microdilution broth
technique, according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. The results show that these two
mandelic acid esters were found to be effective against the tested microorganisms and exert a good antibacterial and
antifungal activity at low concentrations. The oxi-acetyl mandelic acid and oxi-propionyl mandelic acid were included in
0.0125 g % and respectively 0.05 g % concentrations in ointments samples, and it was evaluated the efficiency of the
preservative action for 28 days, in the presence and in the absence of the test microorganisms - Staphylococcus aureus ATCC
25923, Pseudomonas aeruginosa ATCC 27853, Candida albicans ATCC 90028. The tested mandelic acid esters proved to
have a very good preservative action and could be used to preserve ointments in 0.0125 g % and respectively 0.05 g %
concentrations.

Top