FORMULATION AND PREPARATION OF OMEPRAZOL AND
KETOPROFEN BI-LAYER TABLETS BY DIRECT COMPRESSION
METHOD
CARMEN ANATOLIA GAFITANU, MONICA ILIUTA STAMATE*, ILEANA CORNELIA COJOCARU
Department of Pharmaceutical Technology, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy
Iasi, Romania
*corresponding author: cretanmonica@yahoo.com
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Abstract:
The aim of the study was to prepare and characterize bi-layer tablets containing ketoprofen and omeprazole in order to reduce
the side effects of ketoprofen and to improve the therapeutic benefits and patients’ compliance to treatment. Bi-layer tablets
of ketoprofen 100 mg and 20 mg omeprazole (in form of enteric pellets) were prepared by direct compression technique
using carbopol, sodium carboxymethyl cellulose, hydroxypropyl methylcellulose, Kollidon® as matrix-forming agents. These
polymers have the ability to hydrate in digestive fluids and form a gel on the surface of the tablets undergoing erosion
processes in time, in order to control the release of active drugs from compressed matrix tablets. Hardness, friability and
release studies were performed on bi-layer tablets. The results have shown the influence of polymers over the
physicochemical properties and the release profile of the active drugs.

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