PREPARATION AND CHARACTERIZATION OF INCLUSION
COMPLEXES FORMED BY AVOBENZONE WITH β-CYCLODEXTRIN,
HYDROXYPROPYL-β-CYCLODEXTRIN AND HYDROXYPROPYL-α-
CYCLODEXTRIN
RALUCA SBORA¹, EMMA ADRIANA BUDURA1*, GEORGE MIHAI NIŢULESCU2, TEODORA BALACI1, DUMITRU LUPULEASA1
“Carol Davila” University of Medicine and Pharmacy Bucharest, Faculty of Pharmacy, 6 Traian Vuia St., 020956,
Bucharest, Romania
1Pharmaceutical Technology Department
2Pharmaceutical Chemistry Department
*corresponding author: emmacretu@yahoo.com
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Abstract:
The aim of the present study was to confirm the formation of inclusion complexes between avobenzone and betacyclodextrin,
hydroxypropyl-beta-cyclodextrin and hydroxypropyl-alfa-cyclodextrin, using the lyophilisation technique. The
inclusion complexes were subjected to physicochemical characterizations in comparison with the simple physical mixtures
prepared in the same 1:2 (avobenzone : cyclodextrin) molar ratio. The complexes were evaluated by scanning electron
microscopy (SEM), differential scanning calorimetry (DSC), and Fourier-transform infrared spectroscopy (FT-IR). The
inclusion complexes between avobenzone and beta-cyclodextrins, in 1:2 molar ratio, were better concerning all the studied
parameters in comparison with the complexes prepared with alfa-cyclodextrin, probably due to the avobenzone molecule size
which fits better in beta-cyclodextrins than in alfa-cyclodextrins cavity.






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