VALIDATION AND APPLICATION OF A NEW DAD-HPLC METHOD
FOR DETERMINATION OF LORATADINE FROM PHARMACEUTICALS
GEORGETA PAVALACHE1*, VASILE DORNEANU2, ANTOANELA POPESCU1
1”Ovidius” University Constanta, Faculty of Pharmacy, Constanţa, Romania
2”Gr. T. Popa” University, Faculty of Pharmacy, Iasi, Romania
*corresponding author: georgiana_pavalache@yahoo.com
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Abstract:
In our previous research, we developed a DAD-HPLC method for the quantitative determination of loratadine in different
samples [1]. The proposed method was internally validated and its performance parameters were established: linearity,
working range, selectivity, recovery test, accuracy and precision. Validation results showed a good accuracy of the method,
the optimum repeatability and reproducibility. Bias for the accuracy of loratadine assay by HPLC is 100.20%, being in the
recovery range of 95-105%, which shows that the method is accurate. The applicability of the method was verified by
analysing samples from pharmaceutical products containing loratadine (Roletra® Tablets, Clarinase® modified-release
Tablets and Symphoral® syrup).






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