THE EFFECTS OF SOFT MATTER VESICLES ENTRAPPING
MAGNESIUM CHLORIDE IN NOCICEPTIVE REACTIVITY IN MICE
MIHAELA BOANCA1, LILIANA MITITELU-TARTAU1, RAOUL VASILE LUPUSORU2, VLADIMIR POROCH3, NELA BIBIRE4*, CATALINA ELENA LUPUSORU1
1University of Medicine and Pharmacy “Grigore T. Popa”, Faculty of Medicine, Department of Pharmacology-Algesiology,
Universitatii St. no. 16, code 700115, Iasi, Romania
2University of Medicine and Pharmacy “Grigore T. Popa”, Faculty of Medicine, Department of Patho-Physiology,
Universitatii St. no. 16, code 700115, Iasi, Romania
3University of Medicine and Pharmacy “Grigore T. Popa”, Faculty of Medicine, Department of Surgery, Universitatii St. no.
16, code 700115, Iasi, Romania
4University of Medicine and Pharmacy “Grigore T. Popa”, Faculty of Pharmacy, Department of Analytical Chemistry,
Universitatii St. no. 16, code 700115, Iasi, Romania
*corresponding author: nelabibire@yahoo.com
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Abstract:
The study investigates the effects of magnesium nanovesicles on cutaneous nociception assessed using tail immersion test in
mice. Nanoparticles were prepared by magnesium chloride immobilization inside lipid vesicles followed by stabilization with
chitosan. The experiment was carried out on white Swiss mice, divided into 3 groups of 7 animals each, treated orally 7
consecutive days. In tail immersion test, the latency time response was recorded 15, 30, 60, 90 minutes, 2, 4, 6, 8, 10 and 12
hours after substances administration. We developed new carrier formulations that entrapped magnesium chloride in lipid
vesicles with high efficacy and we proved that high stability magnesium nanovesicles can be designed. The administration of
magnesium nanovesicles displayed a prolonged antinociceptive effect compared with the non-entrapped substance in tail
immersion test.

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