EVALUATION OF ANTINOCICEPTIVE ACTION OF BINARY
COMBINATIONS OF SODIUM VALPROATE AND ANALGESIC
DRUGS
LIDIA CRISTINA CHIŢAC1, ILEANA COJOCARU2*, S. BEŞCHEA3, MONICA NEAMŢU1, DELIA BULEA1, VERONICA BILD1
1Department of Pharmacodynamics and Clinical Pharmacy, University of Medicine and Pharmacy, “Grigore. T. Popa” Iaşi
2Department of Pharmaceutical Technology, University of Medicine and Pharmacy, “Grigore. T. Popa” Iaşi
3Department of Toxicology, Faculty of Veterinary Medicine, USAMV Iaşi
*corresponding author: mail.icojocaru@yahoo.com
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Abstract:
In the recent years, substances without a basic analgesic action were used for the treatment of different types of pain, which
do not have a basic analgesic action. Recently, valproic acid was used in combination with some analgesics in the treatment
of various types of pain. This study aimed to identify the type of pharmacodynamic interaction of valproic acid with
analgesics. The study was conducted on mice, using an inflammatory pain model. The results demonstrate the synergism
between valproic acid and tramadol, the subadditivity between valproic acid and paracetamol. These results may lead to
useful hypotheses concerning the action mechanisms of these substances and to the development of binary combinations in
fixed proportion that might represent more effective modalities of treating pain.

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