ENHANCEMENT OF DISSOLUTION RATE OF FENOFIBRATE BY
SPRAY DRYING TECHNIQUE: COMPARISON OF EUDRAGIT E-100,
SOLUTOL® HS15 AND HYDROXYPROPYL CELLULOSE AS CARRIERS
JALEH VARSHOSAZ*, ERFANEH GHASSAMI
Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Centre, Isfahan University of
Medical Sciences, Isfahan, Iran
*corresponding author: varshosaz@pharm.mui.ac.ir
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Abstract:
The aim of the present study was the improvement of the dissolution rate of a poorly water-soluble drug fenofibrate (F) by
using spray drying technique. Dispersions were prepared using Eudragit E-100 (E), Solutol® HS15 (S) and hydroxypropyl
cellulose (HPC) at different ratios (1:1 and 1:5) by the spray drying technique. Aerosil® 200 was used as anti-sticking agent
in FE and FS dispersions. The samples were characterized using X-ray powder diffraction (XRPD), differential scanning
calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR). The morphology of the dispersions was studied by
SEM and the dissolution rates of all samples were determined in comparison with their physical mixtures. The flow
properties of the dispersions were measured by their angle of repose, Carr's index and Hausner ratio. The stability of
dispersions was studied at ambient conditions for a period of 6 months. DSC and XRPD analysis confirmed the presence of
the drug in crystalline state in the dispersions. All dispersions showed a higher dissolution rate than the corresponding
physical mixtures and pure fenofibrte. Except for HPC that showed higher dissolution efficiency (DE) after 2 hours in the
ratio of 1:5, Solutol® had higher DE in 1:1 than 1:5 ratio and in Eudragit there was no significant difference between the ratio
of 1:1 and 1:5. Dispersions of FEA 1:1 showed crystalline state, better flow ability and compressibility than the other two
excipients and showed no remarkable changes in their dissolution profile of the drug after 6 months storage at ambient
conditions.

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