THROMBOPROPHYLAXIS USING LOW MOLECULAR WEIGHT
HEPARINE AFTER ANKLE FRACTURES
GHEORGHE ION POPESCU¹,²#, OLIVERA LUPESCU¹,²#*, CRISTINA PATRU²#, ELENA LUMINITA STANCIULESCU²#, MIHAIL NAGEA², ALEXANDRU DIMITRIU², IOANA CRISTINA GRINTESCU², DORIANA LUPESCU³
¹University of Medicine and Pharmacy Bucharest, 37 Dionisie Lupu, 020022 Bucharest, Romania
²Clinical Emergency Hospital Bucharest, 8 Calea Floreasca, 014461 Bucharest, Romania
³Anesthesia and Intensive Care Unit, Buftea Hospital “Maria Burghele”, 5 Studioului, 70000 Ilfov, Romania
*corresponding author: olivera_lupescu@yahoo.com
#Authors with equal contribution
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Abstract:
Enhanced interest for prophylaxis and multidisciplinary approach of pathology, two main characteristics of modern medicine,
radically changed the classical bone-solely-addressed approach of skeletal trauma. Studies demonstrated the incidence of
Thrombo-Embolic Disease (TED), composed by Deep Venous Thrombosis (DVT) and Pulmonary Embolism (PE) after
orthopaedic pathology, with a significant impact upon morbidity and mortality, thus making thrombo-prophylaxis (TP) an
essential component of trauma treatment. Although there is no clear recommendation for TP following ankle fractures (as in
hip fractures, for example), thrombo-embolic (TE) complications of these injuries have been detailed lately. In this
retrospective study there are evaluated the effectiveness of TP using Enoxaparin sodium, a Low Molecular Weight Heparin
(LMWH), in patients with operated ankle fractures in order to conclude whether prolonged TP after discharge is beneficial or
not. The results of the study demonstrate that TE complications were more frequent when there was no long-term TP, thus
endorsing the recommendations of establishing the TP regimen related to the TE factors, not only to the injury itself.

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