COMPARATIVE IN VITRO DRUG RELEASE EVALUATIONS OF NEW
HYDROGELS CONTAINING OXICAMS
FLAVIAN ȘTEFAN RĂDULESCU1, DALIA SIMONA MIRON2, DOINA DRĂGĂNESCU2*,
SILVIA MARIA STOICESCU3, ANA ANDREEA STĂNESCU4, ADRIAN COSMIN ROȘCA5
University of Medicine and Pharmacy „Carol Davila” Bucharest, Faculty of Pharmacy, 6th Traian Vuia Street, 020956,
Bucharest, Romania
1Department of Drug Industry and Pharmaceutical Biotechnologies
2Department of Pharmaceutical Physics and Informatics
3Department of Obstetrics and Gynecology, Polizu Clinical Hospital, Faculty of Medicine
4Department of Pharmaceutical Technology and Biopharmaceutics
5Ovidius University Constanta, Faculty of Pharmacy, Department of Drug Analysis
*corresponding author: doinadraganescu@yahoo.com
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Abstract:
The paper presents the results of in vitro release and rheological evaluations performed on 12 experimental semisolid dosage
forms containing oxicams as active pharmaceutical ingredient dispersed in hydrophilic matrix. Non-ionic tensioactive agents
were added as both solubility-increasing excipients and absorption promoters. The in vitro release data obtained on a static
vertical diffusion cell system was fitted with two kinetic models, square root law and first order kinetic models. The results
were further analysed in relation with the rheological parameters and underline the critical role of correlated structural and
release evaluations in the selection of optimal formulation candidate, during the research and development phase.

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