THE ROLE OF α1-BLOCKERS IN THE MEDICAL EXPULSIVE
THERAPY FOR URETERAL CALCULI - A PROSPECTIVE CONTROLLED
RANDOMIZED STUDY COMPARING TAMSULOSIN AND SILODOSIN
DRAGOŞ GEORGESCU1, FLORENTINA IONIŢĂ-RADU 2*, RĂZVAN MULŢESCU1, MIHAI
DRAGUŢESCU1 , BOGDAN GEAVLETE1, PETRIŞOR GEAVLETE1, CAROLINA NEGREI3, DAN
MISCHIANU4, MARA GEORGESCU5, OCTAV GINGHINA6
1”Sf. Ioan” Hospital, Department of Urology, “Carol Davila” University of Medicine and Pharmacy, Faculty of Medicine,
13, Vitan-Barzesti Street, 042122, Bucharest, Romania
2Central Universitary Emergency Military Hospital, “Carol Davila’’- Department of Gastroenterology
3Department of Toxicology, “Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, 6, Traian Vuia
Street, 020956, Bucharest, Romania
4Universitary Emergency Central Military Hospital Bucharest, Department of Urology, “Carol Davila” University of
Medicine and Pharmacy, Faculty of Medicine, 134, Calea Plevnei Street, 010825, Bucharest, Romania
5University of Agronomic Sciences and Veterinary Medicine of Bucharest, 59 Mărăşti Blvd, 011464, Veterinary Medicine
Faculty of Bucharest, Bucharest, Romania
6”Sf. Ioan” Hospital, Department of Oncological Surgery, “Carol Davila” University of Medicine and Pharmacy, Faculty of
Dental Medicine, 13, Vitan-Barzesti Street, 042122, Bucharest, Romania
*corresponding author: fionita04@yahoo.com
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Abstract:
In patients with newly diagnosed ureteral stones under 10 mm, observation is an optional initial treatment. The aim of this
prospective trial was to evaluate the efficacy of tamsulosin and silodosin associated with anti-inflammatory drugs by
comparison with anti-inflammatory therapy alone in the medical expulsive treatment of uncomplicated ureteral stones. A
total of 150 patients over 18 years with unilateral, uncomplicated ureteral stones under 1cm were enrolled in a randomized
prospective trial. Subjects in Group I were given tamsulosin 0.4 mg once daily and diclofenac sodium 50 mg/12 h, those in
Group II were given silodosin 8 mg once daily and diclofenac sodium 50 mg/12 h and patients of third group of study only
received the anti-inflammatory medication. In all three groups, drug administration was continued until the patients were
rendered stone-free by intervention or spontaneous stone expulsion, or for a maximum of 4 weeks. Stone expulsion rate was
76% in Group I, in 82% in Group II and 54% in Group III. The statistical analysis demonstrates significant higher expulsion
rate in both study groups by comparison to control group. The difference between the expulsion rates of cases from the
tamsulosin and silodosin groups did not reach statistical significance. The use of tamsulosin and silodosin in medical
expulsive treatment of ureteral stones proved to be safe and effective. The efficacy of both drugs seems to be similar.

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