INFLUENCE OF ENVIRONMENTAL CHLOROFORM
CONCENTRATIONS ON BIOPHYSICS SKIN PARAMETERS
DANIELA CIORBA1*, ALEXANDRU TATARU3, ADRIAN AVRAM3, ALEXANDRA ALMASI4,
MIRELA MOLDOVAN2
1Environment Science Faculty, Babes-Bolyai University, Cluj-Napoca, Romania
2Iuliu Hatieganu University, Medicine Faculty, Dermatologic Clinic, Cluj-Napoca, Romania
3Science Faculty, Aalborg University, Aalborg, Danemark
4Iuliu Hatieganu University, Faculty of Pharmacy, Cluj-Napoca, Romania
*corresponding author: ciorbad@yahoo.com
Download Full Article

Abstract:
Our studies were focused on chloroform effect on skin properties. Three concentrations have been tested 100, 200 and 300
μg/L. These levels of concentrations can be found in swimming pools, where this compound results after the water
chlorination. An original contact method was used, combined with biophysics measurement of several skin parameters: skin
hydration (H), transepidermal water loss (TELW) and sebum secretion (S). Twenty volunteers without clinical signs of
dermatological diseases have been monitored, before and 15 minutes after the contact of the product with the skin. The
recovery was seen after 50 minutes from the beginning. During the contact, skin hydration increased proportionally with the
tested concentrations, while the sebum parameter decreased rapidly. The most important change of TEWL was observed for
100 μg/L, and paradoxically, the return to baseline was higher for 300 μg/L. After 50 minutes, only the sebum parameter
didn’t return to the initial values. The exposures of such environmental concentrations determine the skin drying by sebum
loss, more pronounced if the initial value of the sebum secretion is low.

Top