SYNTHESIS OF SOME NEW 4-METHYL-2-(4-PYRIDYL)-THIAZOLE-
5-YL-AZOLES AS POTENTIAL ANTIMICROBIAL AGENTS
SMARANDA ONIGA1, MIHAELA DUMA2, OVIDIU ONIGA1*, BRINDUSA TIPERCIUC1,
ADRIAN PIRNAU3, CĂTĂLIN ARANICIU1, MARIANA PALAGE1
1Iuliu Hatieganu University of Medicine and Pharmacy, Dept. of Therapeutic Chemistry, 12 Ion Creanga Street, 400010
Cluj-Napoca, Romania
2State Veterinary Laboratory for Animal Health and Food Safety, 1 Marasti Square, 400117, Cluj-Napoca, Romania
3National Institute for Research and Development of Isotopic and Molecular Technologies, 65-103 Donath Street, 400293
Cluj-Napoca, Romania
*corresponding author: smaranda.oniga@umfcluj.ro
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Abstract:
A new series of 4-methyl-2-(pyridin-4-yl)-thiazole-5-yl-azoles were synthesized starting from 4-methyl-2-(pyridin-4-yl)-
thiazole-5-carbohydrazide. The newly synthesized compounds were characterized by analytical 1H NMR, 13C NMR and mass
spectral data. The synthesized compounds were screened for their antimicrobial activities against several strains of Grampositive
and Gram-negative bacteria and one fungal strain (Candida albicans).






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