THE INFLUENCE OF SPLITTING ON THE IN VITRO RELEASE OF
METOPROLOL SUCCINATE FROM SCORED TABLETS
GEORGE TRAIAN ALEXANDRU BURCEA DRAGOMIROIU1, OCTAV GINGHINĂ2, DALIA
SIMONA MIRON3*, MARIA BÂRCĂ1, DANIELA ELENA POPA1, MIRCEA HÎRJĂU4,
DUMITRU LUPULEASA4, FLAVIAN ȘTEFAN RĂDULESCU5
1University of Medicine and Pharmacy “Carol Davila” Bucharest, Faculty of Pharmacy, Department of Drug Control, 6
Traian Vuia street, 020956, Bucharest, Romania
2University of Medicine and Pharmacy “Carol Davila” Bucharest, Faculty of Dental Medicine, Department of Oncological
Surgery, „Sf. Ioan” Hospital, 13 Vitan-Bârzești street, 042122, Bucharest, România
3University of Medicine and Pharmacy “Carol Davila” Bucharest, Faculty of Pharmacy, Department of Pharmaceutical
Physics and Informatics, 6 Traian Vuia street, 020956, Bucharest, Romania
4University of Medicine and Pharmacy “Carol Davila” Bucharest, Faculty of Pharmacy, Department of Pharmaceutical
Technology and Biopharmaceutics, 6 Traian Vuia street, 020956, Bucharest, Romania
5University of Medicine and Pharmacy “Carol Davila” Bucharest, Faculty of Pharmacy, Department of Drug Industry and
Pharmaceutical Biotechnologies, 6 Traian Vuia street, 020956, Bucharest, Romania
*corresponding author: dalia_simona_m@yahoo.com
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Abstract:
The paper presents the results of in vitro release tests applied for assessing the impact of mechanical splitting on the
performance of sustained release oral solid formulations containing metoprolol succinate. Ten multiparticulate drug delivery
systems of the same manufacturer available on the European market, with dose strengths between 23.75 to 190 mg, were
evaluated according to the conditions specified in the United States Pharmacopoeia monograph for six hours. The similarity
of the mean in vitro release profiles was concluded between the split and finished drug product, respectively the
corresponding lower dose. A higher variability of the experimental data was noted for the divided lower strength, probably
due to the reduced reproducibility of the splitting in terms of surface area and morphology. The results demonstrated that the
mechanical splitting didn’t alter the mechanism nor the amount released.






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