PHYTOCHEMICAL AND PHYTOBIOLOGICAL RESEARCH UPON
AERIAL PARTS AND SEEDS FROM PEUCEDANUM OFFICINALE L.
CERASELA ELENA GÎRD, TEODORA COSTEA*, IOANA NENCU, MARIA LIDIA POPESCU,
LIGIA ELENA DUŢU
University of Medicine and Pharmacy ”Carol Davila”, Faculty of Pharmacy, Pharmacognosy, Phytochemistry, Phytotherapy
Department, 6 Traian Vuia Street, 020956, Bucharest, Romania
*corresponding author: teodoracostea85@yahoo.com
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Abstract:
Several samples consisting of aerial parts and seeds from Peucedanum officinale L., harvested from ecologic crops belonging
to S.C. Dacia Plant, Bod, Brasov, Romania were analysed. The aim of our research was the determination of the
phytochemical profile (qualitative and quantitative tests), antioxidant activity (DPPH method) and cytotoxic properties
(phytobiological test, Constantinescu method) of both herbal products. Aerial parts and seeds samples have various contents
of active compounds, depending on the solvent used for extraction, i.e. 0.6517 - 0.7121 g % phenolcarboxylic acids
(expressed as chlorogenic acid), 0.4890 - 0.6050 g % flavonoids (expressed as rutin) and 1.8515 - 2.0047 g % total
polyphenols (expressed as tannic acid) – for aerial parts, 0.7003 - 0.7907 g % phenolcarboxylic acids, 0.8739 - 0.9872 g %
flavonoids and 1.8659 - 2.1519 g % tannic acid – for seeds, respectively. Using HPLC, we have identified chlorogenic acid,
caffeic acid, ferulic acid, rutin and quercetin in both raw materials. The aerial parts have 40.147 mg % rutin and 8.634 mg %
quercetin, while seeds contain 29.4303 mg % rutin and 25.7465 mg % caffeic acid. The seeds have a higher antioxidant
capacity than aerial parts. Bergapten and 8–methoxypsoralen were identified in both samples. These compounds might be
responsible for the cytotoxic effect.

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