SPONGIOUS COLLAGEN-MINOCYCLINE DELIVERY SYSTEMS
MĂDĂLINA GEORGIANA ALBU1, MIHAELA VIOLETA GHICA2*
1National Institute for Textile and Leather Research and Development, Division Leather and Footwear Research Institute,
Collagen Department, 93, Ion Minulescu Str., 031215, Bucharest, Romania
2“Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, Physical and Colloidal Department, 6 Traian
Vuia Str., 020956, Bucharest, Romania
*corresponding author: mihaelaghica@yahoo.com
DownloadDownload Full Article

Abstract:

The purpose of the present work was to develop and characterize some spongious delivery systems based on collagen and
minocycline, uncross-linked and cross-linked with glutaraldehyde, obtained at different freezing temperatures during
lyophilization. The prepared sponges were analysed by scanning electron microscopy and swelling ability. The minocycline
release from collagen spongious systems was investigated and the kinetic mechanism was determined. The results of this
study indicated that the sponges porous architecture, their swelling and also the percentage of drug released are influenced by
both sponges composition and their obtaining process.






Top