NEW THIAZOLIDINE-4-ONES OF FERULIC ACID WITH
ANTIOXIDANT POTENTIAL
MARIA WOLSZLEGER (DRĂGAN)1, CĂTĂLINA DANIELA STAN1, ANDREEA PÂNZARIU2,
ALEXANDRA JITĂREANU3, LENUŢA PROFIRE2*
1Department of Drug Industry and Pharmaceutical Biotechnology,
2Department of Pharmaceutical Chemistry,
3Department of Organic Chemistry,
Faculty of Pharmacy, University of Medicine and Pharmacy “Grigore T. Popa”, 16 Universitatii Street, 700115, Iaşi,
România
*corresponding author: nprofire@yahoo.com
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Abstract:

New thiazolidine-4-one derivatives of ferulic acid have been synthesized in one step ("one-pot") by cyclization of ferulic acid
hydrazide with different aromatic aldehydes and mercaptoacetic acid. The structure of the synthesized compounds was
proved by infrared (IR) and nuclear magnetic resonance (1H-NMR) spectroscopy. The in vitro antioxidant potential of the
synthesized compounds was evaluated according to the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2’-azinobis-(3-
ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging assays. Some of synthesized compounds showed a good
antioxidant activity which supports the favourable influence of the structural modulation on the antioxidant effects of the
ferulic acid.






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