FORMULATION AND IN VITRO RELEASE TESTING OF RECTAL
SUPPOSITORIES CONTAINING NIMESULIDE
ANCA CECILIA NICOARĂ1, RADU GEORGE CAZACINCU2*, DUMITRU LUPULEASA1, DALIA
SIMONA MIRON3, FLAVIAN ȘTEFAN RĂDULESCU4
1University of Medicine and Pharmacy “Carol Davila” Bucharest, Faculty of Pharmacy, Department of Pharmaceutical
Technology and Biopharmaceutics, 6 Traian Vuia street, 020956, Bucharest, Romania
2Ovidius University, Faculty of Pharmacy, 1 Aleea Universitatii, Constanta, Romania
3University of Medicine and Pharmacy “Carol Davila” Bucharest, Faculty of Pharmacy, Department of Pharmaceutical
Physics and Informatics. 6 Traian Vuia street,020956, Bucharest, Romania
4University of Medicine and Pharmacy Carol Davila Bucharest, Faculty of Pharmacy, Department of Drug Industry and
Pharmaceutical Biotechnologies, 6 Traian Vuia street, 020956, Bucharest, Romania
*corresponding author: office@magistracc.com.
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Abstract:

Rectal suppositories containing 100 mg nimesulide were prepared using lipophilic bases with different physico-chemical
characteristics. The experimental protocol implemented for the evaluation of the pharmaceutical quality and in vitro
performance included determinations of softening and disintegration times, as well as the release assessment using a
dissolution equipment with compendial 40 mesh and Palmeri baskets. The mean profiles displayed a very low dissolution of
the lipophilic drug, with release rates influenced on the melting and spreading pattern. The release kinetics was adequately
described by the Higuchi model.

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