SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY
OF CU(II), NI(II), CO(II) AND MN(II) BINUCLEAR COMPLEXES
DERIVED FROM 1,3-BIS(2’-FORMYLPHENYL)-1,3-DIOXAPROPANE
AND L-TRYPTOPHAN
FLORINA CIOLAN1*, LUMINIŢA PATRON2, LUMINITA MARUTESCU3, MARIANA CARMEN
CHIFIRIUC3
1University of Craiova, Faculty of Exact Sciences, Department of Chemistry, 107 I Calea Bucureşti, Craiova, 200478,
Romania
2Romanian Academy, “Ilie Murgulescu” Institute of Physical Chemistry, 202 Splaiul Independenţei, Bucharest, 060021,
Romania
3University of Bucharest, Faculty of Biology, Microbiology-Immunology Department, Aleea Portocalelor 1-3, sect. 5,
Bucharest, Romania
*corresponding author: florina_ciolan@yahoo.com
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Abstract:

A novel series of binuclear complexes of the [M2L(AcO)2(H2O)4] type, where M= Cu(II), Ni(II), Co(II) or Mn(II) and L=
(C39H34N4O6)2-, were synthesized by template condensation of 1,3-bis(2′-formylphenyl)-1,3-dioxapropane, L-tryptophan and
metal acetate in methanolic medium. The complexes of M(II):L (2:1) type were characterized by elemental analyses, molar
conductivity measurements, IR, electronic spectra and magnetic susceptibility measurements. The low value of molar
conductivity indicates them to be non-electrolytes. Based on the magnetic and electronic spectral data, an octahedral /
distorted octahedral geometry may be proposed for all the complexes. The new complexes were screened for their
antimicrobial activity towards ten microbial strains, by qualitative and quantitative assays. Our results indicated that the
[Cu2L(AcO)2(H2O)4] complex was the most active of the studied compounds, concerning both the intensity of the
antimicrobial activity and the microbial spectrum.

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