POLYELECTROLYTE COMPLEXES OF CHITOSAN FOR PRODUCTION
OF SUSTAINED RELEASE TABLETS OF BUPROPION HCL
JALEH VARSHOSAZ*, NASER TAVAKOLI, FATEMEH MOGHADDAM, ERFANEH GHASSAMI
Department of Pharmaceutics, Faculty of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University
of Medical Sciences, Isfahan, Iran
*corresponding author: varshosaz@pharm.mui.ac.ir
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Abstract:

Chitosan (C) has the ability to form hydrogel by polyelectrolyte complexation. Electrostatic attraction among amine group of
chitosan and anion groups of other polyelectrolytes leads to formation of polyelectrolyte complex. The objective of this study
was preparation of Bupropion sustained release tablets by chitosan polyelectrolyte complexes with natural and synthetic
polymers such as Eudragite L100 (E), xanthan (X) and carbopol 934 (CP).
The formation of polyelectrolyte complex between chitosan and aforementioned polymers was confirmed by FT-IR. Then
100 mg bupropion sustained release tablets were prepared by direct compression method at different ratios of each
chitosan/polyelectrolyte complex. The ratio of (C) to (X) in polyelectrolyte complex was 1:1, 1:2, 1:4, 3:4. The ratio of (C) to
(CP) 934 was 1:1, 1:2 and the ratio of (C) to (E) was 3:4, 1:2, 1:4. Physical properties of tablets like: content uniformity,
weight variation, hardness, friability, and dissolution test in 3 mediums (water, HCl 0.1 N and saline buffer phosphate
solution pH 7.4) were evaluated. Drug release from physical mixture with the same ratio of polymers in the complexes was
compared with the polyelectrolyte complexes. Mean dissolution time (MDT) of P C1X1 was significantly greater than other
formulations of C:X series. Among C:CP and their pure polymers, P C1CP1 showed the greatest MDT in water and acidic
medium and among the complexes of C:E, and these pure polymers, P C1E4 in acidic medium showed slower drug release
compared with other formulations in this series. These formulations released bupropion by a Higuchi kinetic model and
showed greater MDT compared to their pure polymers or their physical mixtures in the same ratios.






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