CHARACTERISATION AND CONTROLLED RELEASE PROPERTIES
OF ENTANDOPHRAGMA ANGOLENSE GUM IN IBUPROFEN MATRIX
TABLETS
OLADAPO A ADETUNJI, MICHAEL A ODENIYI*, OLUDELE A ITIOLA
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria
*corresponding author: deleodeniyi@gmail.com
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Abstract:

A novel hydrophilic polymer, Entandophragma angolense gum (ENTA), was characterized and incorporated as excipient in
Ibuprofen tablet matrices prepared by direct compression. Comparisons were made with formulations incorporating Gelatin
or Hydroxypropylcellulose. The gum was analysed by X-ray Diffraction and drug-polymer interactions were assessed by
Fourier-Transform Infrared (FTIR) spectrometric studies. Mechanical properties of matrices were assessed using crushing
strength (CS) and friability (F). In vitro drug release studies were conducted for 24 hours at 37 ºC in phosphate buffer pH 7.2
dissolution medium. The results were fitted into kinetic models to determine the drug release mechanism. There were no
interactions between Ibuprofen and ENTA. Increased polymer content led to an increase in CS and a decrease in F values.
The ranking of the CS was Hydroxypropylcellulose > ENTA > Gelatin, while the ranking was reversed for F. The ranking of
the time for 25% drug release, at 80%w/w polymer concentration was ENTA > Hydroxypropylcellulose > Gelatin. The
release kinetics determined using the Akaike criterion Index indicate Korsemeyer supercase II model at high concentrations
of the gum. Incorporation of Entandophragma angolense gum enhanced the mechanical properties of Ibuprofen matrix
tablets and also the controlled drug release.

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