CURRENT KNOWLEDGE ON BUPROPION AND VARENICLINE
CLINICAL EFFICACY IN NICOTINE DEPENDENCE
MARINELA CHIRILA1*, ISABEL GHITA1, ION FULGA1
1University of Medicine and Pharmacy “Carol Davila”, Bucharest, Department of Pharmacology and Pharmacotherapy
*corresponding author: marinella_pantazi@yahoo.com
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Abstract:

Abstract
The purpose of this paper was to investigate the efficacy of bupropion and varenicline for treating nicotine dependence as
reported in the published studies. We analysed 435 journal articles identified in Pubmed data base with “nicotine,
dependence, bupropion / varencline” included in abstract. The “human” filter was applied. 20 efficacy studies were selected
and included for evaluation in this review. The results of these studies support the efficacy of both bupropion and varenicline,
with varenicline showing higher abstinence rates. However in real life settings high levels of efficacy are lacking for all
current available treatments. In addition, treatment related side effects highly influence the patient compliance.






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