ANTIOXIDANT ENZYMES - POTENTIAL
TARGETS IN INTRACEREBRAL HAEMORRHAGE
TOMA PAPACOCEA1, IOAN BURAGA2, RALUCA PAPACOCEA3*,
IOANA ANCA BADARAU3, MAGDA BURAGA3, CATALINA
CIORNEI3, GRAŢIELA MIHAI3, IRINA STOIAN4, ADAM DANIL1
1Emergency Hospital “St. Pantelimon”, Department of Neurosurgery,
340 Pantelimon, 21659 Bucharest, Romania
2Clinical Hospital Colentina, Department of Neurology, 19-21 Ștefan cel
Mare 020125 Bucharest, Romania
3Physiology Department I, “Carol Davila” University of Medicine and
Pharmacy, 8 Eroilor Sanitari, 050474, Bucharest Romania
4Biochimistry Department, “Carol Davila” University of Medicine and
Pharmacy, 8 Eroilor Sanitari, 050474, Bucharest Romania
*corresponding author: rpapacocea@gmail.com
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Abstract:

Intracerebral haemorrhage (ICH) is accompanied by a cascade of pathological
events which involves the generation of oxygen and nitrogen reactive species. These very
short lifetime molecules change the level of antioxidant mechanisms, including antioxidant
enzymes. The aim of our study was to assess the superoxide dismutase (SOD), glutathione
peroxidase (GPx), glutathione reductase (Gred), glutathione transferase (GTS) activities.
The level of oxidative damage was underlined by malondialdehyde (MDA) as index of lipid
peroxidation .We also assessed the total nitrite level.
The measurements were performed on cerebrospinal fluid (CSF) samples from
21 patients and 15 healthy volunteers.
We found significantly increased SOD and GPx and reduced Gred and GST
activities in CSF of ICH patients. MDA and total nitrate levels were both increased.

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