COMPATIBILITY AND STABILITY STUDIES OF
ANTIHYPERTENSIVE/EXCIPIENTS BY
THERMAL METHODS, USED IN THE
PREFORMULATION PHASE
ANCA MOISEI1, FELICIA GLIGOR1*, MARIUS BOJIŢĂ2, ADRIANA
CHIŞ1, MARIA TOTAN1, LOREDANA ANDREEA VONICA-GLIGOR1,
ADRIANA CIURBA3
1“Lucian Blaga” University, Sibiu
2“Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca
3University of Medicine and Pharmacy of Tîrgu Mureş, Romania
*corresponding author: felicia.gligor@ulbsibiu.ro
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Abstract:

The objective of this study was to investigate the quality of the interactions
between the active antihypertensive substances and the possible excipients in order to guide
the preformulation process of a triple layered tablet. The active substances chosen were
Candesartan Cilexetil (CC), Amlodipine Besylate (AB), Hydrochlorothiazide (HCTZ) and
the excipients were Croscarmellose sodium (AcDiSol), Magnesium Stearate (StMg), and
Colloidal silica (Aerosil)...






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