EXPERIMENTAL TECHNIQUES EMPLOYED IN
THE STUDY OF METAL COMPLEXES-DNA –
INTERACTIONS
TAMARA TOPALĂ1*, ANDREEA BODOKI1, LUMINIŢA OPREAN1,
RADU OPREAN2
1 Department of General and Inorganic Chemistry, Faculty of Pharmacy,
“Iuliu Hațieganu” University of Medicine and Pharmacy Cluj-Napoca,
Romania
2 Department of Analytical Chemistry and Instrumental Analysis, Faculty
of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy
Cluj-Napoca, Romania
*corresponding author: topala.liana@umfcluj.ro
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Abstract:

The present paper is an overlook on metal complexes-DNA interactions, their
classification and the experimental techniques employed to study them. The
deoxyribonucleic acid (DNA), as the vector for genetic information in living organisms, is
one of the main targets for pharmacologically active molecules, especially for anticancer
agents. Understanding how drugs interact with DNA is of outmost importance as
researchers struggle to design more efficient and specifically targeted therapeutics, with
fewer side effects. As in the recent years bioinorganic chemistry has provided numerous
examples of compounds with high affinity towards DNA, the present review focuses on
transition metal complexes.

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