THE SYNERGISTIC ANTINOCICEPTIVE
INTERACTION OF CODEINE AND PREGABALIN
IN A SOMATIC PAIN MODEL IN MICE
ELIZA GRATIELA POPA1, LILIANA MITITELU TARTAU2*, RAOUL
VASILE LUPUSORU3, CATALINA ELENA LUPUSORU2, IULIAN
STOLERIU4, LACRAMIOARA OCHIUZ1
1University of Medicine and Pharmacy “Grigore T. Popa”, Faculty of
Pharmacy, Department of Pharmaceutical Technology, Universitatii st.
no. 16, code 700115, Iasi, Romania
2University of Medicine and Pharmacy “Grigore T. Popa”, Faculty of
Medicine, Department of Pharmacology-Algesiology, Universitatii st. no.
16, code 700115, Iasi, Romania
3University of Medicine and Pharmacy “Grigore T. Popa”, Faculty of
Medicine, Department of Patho-Physiology, Universitatii st. no. 16, code
700115, Iasi, Romania
4University “Al. I. Cuza”, Faculty of Mathematics, Carol I Bld, code
700506, Iasi, Romania
* corresponding author: lylytartau@yahoo.com
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Abstract:

We aimed to investigate the effects of pregabalin (PGB) and codeine (COD)
combination in a somatic pain model (the tail flick test) in mice. In this experiment the
substances were administered orally separately and in association; the tail withdrawal reflex
latencies, as a response to thermal noxious tail stimulation, were registered at 0, 30, 60 and
90 minutes after substances administration. Differences between the experimental and
baseline latencies were interpreted as an index of analgesia. Response latency data from tail
flick measurements were also converted to per cent of maximum possible effect. In our
experimental conditions oral administration of PGB-COD combination was associated with
a stronger increase of latency time response, statistically significant after 15 minutes
compared to control group, and to the groups treated with PGB, respectively COD in the
tail flick test. We can conclude that oral administration of pregabalin proved to potentiate
the antinociceptive effects of codeine in this somatic pain model in mice.

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