IN VITRO ESTROGENIC/ANTI-ESTROGENIC
EFFECTS OF CERTAIN FOOD ADDITIVES AND
COSMETIC PRESERVATIVES
ANCA POP1, BELA KISS1*, TUDOR DRUGAN2, JULIEN CHERFAN1,
FELICIA LOGHIN1
1“Iuliu Haţieganu” University of Medicine and Pharmacy, Faculty of
Pharmacy, Department of Toxicology, Cluj-Napoca, Romania
2“Iuliu Haţieganu” University of Medicine and Pharmacy, Faculty of
Medicine, Department of Medical Informatics and Biostatistics, Cluj-
Napoca, Romania
* corresponding author: kbela@umfcluj.ro; kissbela@gmail.com
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Abstract:

In the present study we evaluated the estrogenic/anti-estrogenic effects of
butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), propyl gallate (PG) and
butyl paraben (BP), compounds extensively used as antioxidants/conservatives in food,
food packaging, cosmetics and pharmaceuticals, using the luciferase assay. BP and PG
were found out to have dual effect. BHA was discovered to have only anti-estrogenic
effects, while BHT was the only compound tested in the present studies that did not have
any effect.






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