STUDY ON THIAMPHENICOL – INDUCED SIDE
EFFECTS IN HAMSTERS
MARIA CRIVINEANU1, MANUELLA MILITARU1, DENISA IOANA
UDEANU2, VALENTIN NICORESCU1*, CAMELIA PAPUC1, CORINA
ANA IONIȚĂ2, ELENA ROTARU1
1University of Agronomic Sciences and Veterinary Medicine of
Bucharest, Faculty of Veterinary Medicine, 105 Splaiul Independentei,
050097, Bucharest, Romania
2University of Medicine and Pharmacy “Carol Davila”, Faculty of
Pharmacy, 2 Traian Vuia, Bucharest
* corresponding author: valinicorescu@yahoo.com
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Abstract:

The present study investigated the possible adverse effects of thiamphenicol in
hamsters following the administration of therapeutic doses. Thiamphenicol was
administered by intramuscular injection at a dose rate of 35 mg/kg body weight once daily
for 7 days. Functional changes of bone marrow, liver and kidney were monitored; bone
marrow cytology and histopathology of the liver, kidneys and heart were performed.
Enzymatic markers of hepatic cell damage were slightly increased in the treatment groups.
Urea and creatinine concentrations were higher in thiamphenicol-treated hamsters than in the
control group, suggesting an alteration in renal function. Haematology parameters were altered
in thiamphenicol-treated hamsters and bone marrow smears showed slight bone marrow
depression affecting all haematopoietic cell lines. Following histopathological investigations,
no changes in liver morphology could be observed. Isolated degenerative changes were
observed in the proximal convoluted tubule epithelium, without loss of integrity or changes
in renal architecture. Myocardial arteriole and capillary stasis and incipient haemolysis
were observed as well as alterations in longitudinally sectioned myocardiocytes.

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