THE LEVELS OF SERUM BIOMARKERS OF
INFLAMMATION IN HEMODIALYSIS PATIENTS
ANGELA ANTONESCU1, SIMONA IOANA VICAS2*, ALIN C.
TEUSDEA2, IOANA RATIU3, INA ANDREEA ANTONESCU4, OTILIA
MICLE1, LAURA VICAS6, MARIANA MURESAN1, FELICIA GLIGOR5
1University of Oradea, Faculty of Medicine and Pharmacy Oradea,
Department of Preclinical Disciplines, Oradea, Romania
2University of Oradea, Faculty of Environmental Protection, Oradea,
Romania
3University of Oradea, Faculty of Medicine and Pharmacy Oradea,
Department of Internal Medicine, Oradea, Romania
4County Clinical Emergency Hospital Oradea, Romania
5University “Lucian Blaga”, Sibiu, Faculty of Medicine and Pharmacy
Oradea, Department of Pharmacy
6University of Oradea, Faculty of Medicine and Pharmacy Oradea,
Department of Pharmacy, Oradea, Romania
* corresponding author: sim_vicas@yahoo.com
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Abstract:

Leptin controls metabolism, energy balance and can also intensify inflammation
by inducing mononuclear cell activation and proliferation. It realizes this last effect by
stimulating the production of pro-inflammatory cytokines such as interleukine-6 (IL-6),
tumour necrosis factor α (TNF-α), interleukine-8 (IL-8). The objective of the present study
was to investigate the serum levels of IL-6, IL-8 and TNF-α and leptin in chronic renal
failure patients submitted to haemodialysis.
In this study there were included two groups of subjects, one of them being
chronic renal failure patients submitted to haemodialysis (n=60) and the other group was
represented by healthy volunteers (n=30). Serum levels of inflammatory cytokines (IL-6,
IL-8, TNF-α) and leptin were assessed before and after haemodialysis.
Leptin levels (9.609 ± 6.775 ng/mL) were high in haemodialysis patients if
compared to the control group (4.585 ± 1.302 ng/mL) and after dialysis the concentration
has decreased (6.466 ± 4.008 ng/mL). The concentrations of TNF-α (25.280 ± 4.640
pg/mL), IL-6 (8.073 ± 4.608 pg/mL) and IL-8 (34.370± 9.104 pg/mL) were high in patients
submitted to haemodialysis in comparison with the group of healthy volunteers TNF-α
(6.877 ± 1.447 pg/mL), IL-6 (2.014 ± 0.046 pg/mL), IL-8 (18.090 ± 5.840 pg/mL).
Haemodialysis patients showed elevated levels of leptin, IL-6, IL-8 and TNF-α.
After dialysis it was observed a significant decrease of leptin level (p = 0.0091), whereas
IL-8 increased significantly (p < 0.0001).






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