ASSESSMENT OF SOME OXIDATIVE STRESS
PARAMETERS IN METHOTREXATE TREATED
PSORIASIS PATIENTS
DANIEL BODA1, CAROLINA NEGREI2*, FLORICA NICOLESCU2,
CRISTIAN BĂLĂLĂU3
1Dermato-oncology Excellence Research Center “Carol Davila”
University of Medicine and Pharmacy, 22-24, Gr. Manolescu Street,
Bucharest, Romania
2Toxicology Department, “Carol Davila” University of Medicine and
Pharmacy, 6, Traian Vuia street, Bucharest, Romania
3Department of General Surgery, University of Medicine “Carol Davila”,
Emmergency Universitary Hospital “St. Pantelimon”, Bucharest
* corresponding author: carol_n2002@hotmail.com
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Abstract:

Psoriasis is a chronic inflammatory skin disease. Reactive oxygen species
produced in result of skin inflammation may cause disorders of the antioxidant defence systems and increased oxidative stress in psoriasis. The aim of the study was the assessment of certain redox stress parameters in methotrexate (MTX) treated psoriasis patients
compared to a control group.
The study included 28 patients diagnosed with psoriasis according to clinical criteria and included into groups according to Psoriasis Area and Severity Index (PASI) score and treated with MTX. The control group included 32 healthy volunteers. We assessed the plasma levels of malondialdehyde (MDA) and total antioxidant status (TAS) (spectrophotometrically measured), as well as the PASI score of clinical progress.

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