COMPARATIVE STUDY REGARDING
CELIPROLOL AND METOPROLOL USE IN THE
TREATMENT OF ESSENTIAL ARTERIAL
HYPERTENSION
SORINA LIVIA POP1*, CODRUȚA MĂRGINEAN1, SIMONA MIREL2,
DANIEL MUREȘAN1, DANIELA POP VORNICESCU1, RAREȘ
GHERMAN1, EMIL ONACĂ1
“Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca
1Faculty of Medicine
2Faculty of Pharmacy
* corresponding author: sorinacdt@yahoo.com
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Abstract:

The effects of β–blockers in essential arterial hypertension (EAHT) are well
known. The main objective of our study was to study comparatively the efficacy and the safety of the administration of two representatives of this class: celiprolol versus metoprolol, in equivalent doses, over a 2 weeks period. Unlike metoprolol, celiprolol is a cardioselective beta 1-blocker, with a moderate intrinsic beta 2-sympathomimetic action and minimal vasodilatatory effects. Metoprolol and celiprolol were initially administered in
doses of 6.25 mg twice a day and 50 mg a day, respectively; the doses were increased every 3 days, under careful clinical monitoring, up to 50 mg twice a day and 200 mg a day, respectively, a normalization of blood pressure values being obtained. We also monitored the occurrence of the most frequent side effects of beta-blockers: bradycardia, fatigue, cold
extremities. Only minor side effects were registered, which did not require the suppression of treatment. No significant changes in laboratory tests were found.

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