THE INFLUENCE OF TWO SYNTHESISED
PROSTAMIDES ON OXIDATIVE STRESS
INDUCED IN RAW264.7 MACROPHAGE MURINE
CELL LINE
SORINA NICOLETA PETRACHE VOICU1, DENISA IOANA
UDEANU*2, ANCA DINISCHIOTU1, CORINA ANA IONIȚĂ2
1Department of Biochemistry, Faculty of Biology, University of
Bucharest, 91-95 Splaiul Independenței, sector 5, Bucharest, Romania
2Department of Clinical Laboratory and Food Safety, Faculty of
Pharmacy, University of Medicine and Pharmacy ”Carol Davila”, 6
Traian Vuia Str., sector 2, Bucharest, Romania
* corresponding author: denisaudeanu@gmail.com
DownloadDownload Full Article

Abstract:

Prostamides are lipid mediators biosynthesised via COX-2 from anandamide (arahidonylethanolamide). The aim of this study was to determine the possible toxicity of prostamides after their peroxidation on RAW264.7 macrophage murine cell line. In the presence of 10μM H2O2 and the studied prostamides, in RAW 264.7 macrophage murine
line an oxidative stress occurred, demonstrated by the increase of malondialdehyde (MDA) and protein oxidation levels in a time dependent manner.






Top