ANTINOCICEPTIVE PROPERTIES OF
DIETHYLAMINE IN RODENTS: ROLE OF THE
CANNABINOID AND OPIOID RECEPTORS
ANA SEGĂRCEANU*, ISABEL GHIȚĂ, AIDA CRISTINA SOVA,
MIRCEA CRISTIAN RADU, ION FULGA
1Department of Pharmacology and Pharmacotherapy – Faculty of
Medicine – University of Medicine and Pharmacy “Carol Davila”
Bucharest – 8, Eroilor Sanitari Street, 050474, Bucharest, Romania
* corresponding author: anna_sega@yahoo.com
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Abstract:

Diethylamine is a simple substance for which analgesic properties were proven but the underlying mechanism of action is unknown. The working hypothesis of this research was that the diethylamine could produce analgesia by interacting with the endocannabinoid system. The aim of this study was to investigate the interaction of diethylamine with cannabinoid or opioid receptors on chemical and thermal pain models in mice or rats...






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