THE DYNAMICS OF ADIPONECTIN AND LEPTIN
ON METABOLIC SYNDROME PATIENTS AND
AGE MATCHED HEALTHY SUBJECTS
MOHAMAD ABDULWAHABE MOHAMAD1, NICULINA MITREA1,
ALINA-CRENGUȚA NICOLAE1*, MARIA-ZINAIDA CONSTANTINESCU1,
CRISTINA MANUELA DRĂGOI1, ANDREEA-LETIȚIA ARSENE1,
CARMEN GABRIELA BARBU2,3
1Biochemistry Departament, „Carol Davila” University of Medicine and
Pharmacy, Faculty of Pharmacy, Traian Vuia St. 6, Bucharest, Romania
2Endocrinology Department, „Carol Davila” University of Medicine and
Pharmacy
3Elias Emergency University Hospital, Mărăști St. 17, Bucharest
* corresponding author: alinanicolae29@gmail.com
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Abstract:

The metabolic syndrome is a complex combination of interrelated risk factors of metabolic origin that, when occurring together, increase the risk of developing cardiovascular disease and diabetes.
Adipocytokines are bioactive mediators released from the adipose tissue
including adipocytes and other cells present at the level of fat tissues. These include several novel and highly active molecules released abundantly by adipocytes like leptin, resistin, adiponectin, as well as some more classical cytokines released possibly by inflammatory cells infiltrating fat, like tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6).
The most abundantly expressed cytokines within the adipose tissue are leptin and adiponectin [1, 3]..

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