SYNTHESIS OF NEW 2-PHENYLAMINO-5-[(α-ACYLAMINO)-p-X-STIRYL]-1,3,4-THIADIAZOLE COMPOUNDS
TUNDE HORVATH1*, GEORGETA ŞERBAN1, STELA CUC2
1University of Oradea, Faculty of Medicine and Pharmacy, Pharmaceutical Chemistry Department, 29 Nicolae Jiga, 410028 Oradea, România
2University of Waterloo, Department of Earth Sciences, Environmental Isotope Laboratory, Waterloo, Ontario, Canada
* corresponding author: tundeh75@gmail.com
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Abstract:

Cyclization of 4-phenyl-1-[α-acylamino-β-(p-X-phenyl)]acriloyl thiosemicarbazides 2a-h with concentrated sulfuric acid conduCted to 2-phenylamino-5-[(α-acylamino)-p-X-stiryl]-1,3,4-thiadiazole 3a-h. The newly synthesized compounds structures were elucidated by elemental analysis and spectral data.






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