RETHINKING CARDIOVASCULAR THERAPY -
THE EFFECT OF IRBESARTAN ON
CIRCULATING MICROPARTICLES AND
ENDOTHELIAL PROGENITOR CELLS IN
PATIENTS WITH HYPERTENSION AND
DYSLIPIDEMIA
ELISABETA BĂDILA1,2, ANA MARIA DARABAN1, SILVIU
GHIORGHE1, ADRIANA GEORGESCU3, NICOLETA ALEXANDRU3,
DANIELA BARTOŞ1,2, CRISTINA TÎRZIU1*
1 Clinical Emergency Hospital, Bucharest, Romania
2”Carol Davila” University of Medicine and Pharmacy, Romania
3”Nicolae Simionescu” Institute of Cellular Biology and Pathology,
Bucharest, Romania
*corresponding author: tirziuc@yahoo.com
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Abstract:

Endothelial progenitor cells (EPCs) and circulating microparticles (MPs) have been proposed as markers of endothelial function. In turn, the protective role of irbesartan, an angiotensin receptor blocker, on the endothelium has been demonstrated in the recent years but the mechanism has not been yet fully elucidated. In this context, we investigated whether irbesartan can influence these two new biomarkers in patients with cardiovascular (CV) risk factors.






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