EXPERIMENTAL RESEARCH ON POSSIBLE
INTERACTIONS OF HIGH DOSES OF
METAMIZOLE SODIUM WITH THE
ENDOGENOUS CANNABINOID OR
DOPAMINERGIC SYSTEMS
LAURENŢIU COMAN1, HORIA PĂUNESCU*1, OANA ANDREIA
COMAN1, LUMINIŢA CRISTINA CHIUŢU2, ION FULGA1
1Faculty of Medicine and Pharmacy, UMF Carol Davila, Bucharest
1UMF Craiova, Faculty of Medicine
*corresponding author: phpaunescu@yahoo.com
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Abstract:

For metamizole sodium the four specific effects of cannabinoids in mice were previously noticed by us (the tetrad): analgesia, sedation, hypothermia, catalepsy. For verifying the cannabinoid hypothesis, the effects of the association between metamizole sodium 1g/kg bw and a CB1 receptors antagonist (AM281) in the hot-plate test and on body temperature were tested in mice. The results showed that metamizole in high doses possessed a central analgesic and hypothermic effect, but they were not influenced by the CB1 receptors antagonist. These findings suggested that the demonstrated analgesic and hypothermic effects of metamizole do not involve a cannabinoid mechanism.

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