IMPROVED ACTIVITY OF AMINOGLYCOSIDES
ENTRAPPED IN SILICA NETWORKS AGAINST
MICROBIAL STRAINS ISOLATED FROM
OTOLARYNGOLOGICAL INFECTIONS
ION ANGHEL1,2*, ALEXANDRU MIHAI GRUMEZESCU3, ALINA
MARIA HOLBAN4, IRINA GHEORGHE4, MIHAELA VLAD3,
GEORGIANA ALINA ANGHEL5, PAUL CATALIN BALAURE3,
CARMEN MARIANA CHIFIRIUC4, IOANA MIHAIELA CIUCA6
1University of Medicine Carol Davila Bucharest, Romania
2Doctor Anghel Medical Center, Theodor Sperantia Street, Bucharest,
Romania
3 Politehnica University of Bucharest, Faculty of Applied Chemistry and
Materials Science, Bucharest, Romania
4University of Bucharest, Faculty of Biology, Microbiology Immunology
Department, Bucharest, Romania
5ENT (Otorhinolarynqology) Clinic, Coltea Hospital, Bucharest,
Romania
6Pediatrics Department, Victor Babes University of Medicine and
Pharmacy Timisoara, Romania
*Corresponding author e-mail address: dr_alina.anghel@yahoo.com
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Abstract:

The purpose of this study was to investigate the efficiency of natural and
synthetic zeolites as carriers for aminoglycoside antibiotics,by using an adapted diffusion method and microbial strains isolated from otolaryngological infections. The results showed that the natural and synthetic zeolites proved to be excellent carriers for aminoglycosides, exhibiting a strong potentiator effect on the activity of kanamycin and
streptomycin, especially against the Gram-positive bacterial strains, as demonstrated by the drastic increase of the growth inhibition zone diameters induced by the antibiotics entrapped in the silica networks. These results are demonstrating the utility of silica networks in the pharmaceutical industry for the identification of new ways to improve the
bioavailability and dissolution of the currently used antibiotics.

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