THE INFLUENCE OF SOME PSYCHOTROPIC
SUBSTANCES ON CONDITIONING USING AN
ACTIVE AVOIDANCE PARADIGM
ANCA BUZESCU1, SIMONA NEGREŞ1*, MARA LEFTER1, BRUNO
ŞTEFAN VELESCU1, EMIL ŞTEFĂNESCU1, CORNEL CHIRIŢĂ1,
FLORICA NICOLESCU2
University of Medicine and Pharmacy ”Carol Davila”, Faculty
of Pharmacy, Traian Vuia str. no. 6, Bucharest, Romania
1Department of Pharmacology and Clinical Pharmacy
2Department of Toxicology
*corresponding author: simona_negres@yahoo.com
Download Full Article

Abstract:

The reflexes represent the quick, involuntary responses of the organism to a stimulus. The mechanisms of both innate and acquired reflex involve the glutamatergic and the dopaminergic transmissions. The aim of this research was to investigate the effect of haloperidol and monosodium glutamate on the formation of conditioned reflex in an active avoidance test, using Wistar rats. Monosodium glutamate(E621, MSG), the sodium salt of
glutamic acid, is regulated in the EU as a flavour enhancing agent (E 621). Haloperidol is an antipsychotic, blocker of D2 receptors. The results obtained indicate that the two substances have a negative influence on the formation of conditioned reflexes.

Top