BRAIN DERIVED NEUROTROPHIC FACTOR
LEVELS AND HIPPOCAMPAL VOLUME IN
DEPRESSED PATIENTS TREATED WITH
ESCITALOPRAM
MARIA LADEA1,2*, MIHAI BRAN3, MIRCEA MEDREA4
1“Carol Davila” University of Medicine and Pharmacy, Bucharest
2Clinical Hospital of Psychiatry “Prof. Dr. Alexandru Obregia”, Bucharest
3Clinical Hospital Coltea, Bucharest
4Medinst Diagnostic Romano-German
*corresponding author: maria_ladea@yahoo.com
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Abstract:

Recent studies suggest the important roles of brain derived neurotrophic factor (BDNF) and hippocampal volume in the etiopathogenesis of the depressive disorder and also in the mechanisms of action of some antidepressants. The aim of this study was to find possible correlations between serum levels of BDNF, hippocampal volume and clinical symptoms in patients with major depressive disorder (MDD), before, during and after 6
months treatment with escitalopram. Forty female subjects were included: 20 women diagnosed with MDD and 20 aged-matched healthy female controls (without medication).

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