PREPARATION AND CHARACTERIZATION OF
POLYMETHACRYLATE-BASED MATRIX
MICROSPHERES OF CARBAMAZEPINE USING
SOLVENT EVAPORATION METHOD
HIRAK KUMAR MUKHOPADHYAY 1,2, SANJOY KUMAR DAS1,
MANAS BHOWMIK3, SUBHABRATA RAY4, RAJAN
RAJABALAYA5*, LAKSHMIKANTA GHOSH2, BIJAN KUMAR
GUPTA2
1Institute of Pharmacy, Jalpaiguri, Pin-735101, West Bengal, India.
2Department of Pharmaceutical Technology, Jadavpur University,
Kolkata-700032, West Bengal, India.
3Department of Pharmaceutics, Himalayan Pharmacy Institute, Majhitar,
East Sikkim-737136, India.
4Bengal School of Technology, Sugandha, Delhi Road, P.O.: Sugandha,
Dist.: Hooghly,
Pin-712 102, West Bengal, India.
5School of Pharmacy, International Medical University, No.126, Jalan Jalil
Perkasa 19, Bukit Jalil, 57000 Kuala Lumpur, Malaysia.
*corresponding author: rajan _rajabalaya@imu.edu.my
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Abstract:

The purpose of the present investigation was to prepare carbamazepine loaded Eudragit® microspheres able to modify the release profile of carbamazepine by emulsionsolvent evaporation technique. The effect of polymer, Eudragit® RSPO and Eudragit® RLPO alone and in combinations of these two acrylate polymers in different concentrations and in different drug polymer ratios on percentage yield, particle size, entrapment efficiency, and in vitro drug release behavior had been investigated. A mixed solvent system (MSS) consisting of acetonitrile and dichloromethane in a 1:1 ratio and corn oil was selected as primary and secondary oil phases, respectively. Span 80 was used as the secondary surfactant for stabililizing the external oil phase.

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