TESTOSTERONE SUPPLEMENTS ACCELERATE
PROGRESSION OF KIDNEY INJURY IN A RAT
MODEL OF REDUCED RENAL MASS
RADU ILIESCU1,2, *, MONICA HĂNCIANU3, JANE F. RECKELHOFF2
1Department of Physiology, University of Medicine and Pharmacy “Gr.
T. Popa” Iasi,16 Universitatii St., Iasi, Romania,
2Department of Physiology, University of Mississippi Medical Center,
2500 North State St., Jackson, MS, USA
3Faculty of Pharmacy, University of Medicine and Pharmacy “Gr. T.
Popa” Iasi,16 Universitatii St., Iasi, Romania,
*corresponding author: radu.iliescu@umfiasi.ro
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Abstract:

Men with end-stage renal disease are frequently given androgen supplements to improve sexual function. Endogenous androgens contribute to hypertension and renal injury in various animal models. We hypothesized that testosterone supplements exacerbate hypertension and renal injury in rats with reduced renal mass (RRM). Rats subjected to surgical ablation of 80% of renal mass were given 8% NaCl diet for 6 weeks. Testosterone
was administered in Silastic® pellets throughout the study to groups of rats with intact or ablated kidneys. Arterial pressure was continuously monitored by telemetry. Renal injury was assessed by measurements of urinary protein and neutrophil gelatinase-associated lipocalin (NGAL) excretion.

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