FORMULATION AND PREPARATION OF
ORALLY DISINTEGRATING TABLETS USING
INNOVATIVE BINDER
GRAŢIELA POPA1, LĂCRĂMIOARA OCHIUZ1*, IULIAN
STOLERIU2, ILEANA COJOCARU1, IULIANA POPOVICI1
1University of Medicine and Pharmacy „Gr. T. Popa” Faculty of
Pharmacy, 16 Universităţii St., 700115, Iasi, Romania
2University „Al. I. Cuza” Iasi, Faculty of Mathematics, Carol I Bld,
700506, Iasi, Romania
*corresponding author: ochiuzd@yahoo.com
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Abstract:

The present study investigates the use of glyceryl palmitostearate (Precirol ATO 5 – coded PATO) as binder in orally disintegrating tablets (ODT), prepared by melt granulation. PATO has been mentioned in literature for its lipophilic nature and fine powder properties, providing excelent coating and slow release of active drugs, but it can also be used for taste masking purposes, with possible applications in ODT. In order to use it as an ODT excipient, some challenges must be overcome, given its lipophilicity. Our first goal was to study its potential to improve tablet properties (hardness, friability, disintegration time) and provide fast release of the model drug, by setting the optimal proportion to be used in ODT.

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