OPTIMIZATION OF METOPROLOL
TARTRATE MODIFIED RELEASE MATRIX
TABLETS FORMULATION USING SURELEASE
AS BINDER FOR GRANULATION
CRISTIAN ALECU1, IOAN TOMUȚĂ2*, DANA DUDAS2, SORIN
LEUCUȚA2, CONSTANTIN MIRCIOU3
1 SC Laropharm SRL, Bucuresti, Romania
2University of Medicine & Pharmacy „Iuliu Haţieganu”, Cluj-Napoca,
Romania
3 University of Medicine & Pharmacy„Carol Davila”, Bucharest,
Romania
* corresponding author: tomutaioan@umfcluj.ro
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Abstract:

The aim of this experimental work was to evaluate the influence of formulation variables on drug (metoprolol tartrate) release during a period of 12 hours, using a statistical method, in order to prepare sustained release matrix type tablets. A full factorial experimental design with two factors and three levels was used. The formulation factors were the matrix-forming polymer concentration (hydroxypropylmethylcellulose) and the
granulation polymer concentration (ethylcellulose). The dependent variables were the percent of metoprolol released at different periods of time and k release constant and n exponent of the Peppas equation.






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