EXPERIMENTAL PHARMACOLOGICAL MODEL
FOR INDUCING AND QUANTIFYING
DEPRESSION IN MOUSE
SIMONA NEGREŞ1, CRISTINA ELENA ZBARCEA1*, ANDREEA
ARSENE2, CORNEL CHIRIŢĂ1, ANCA BUZESCU1, BRUNO
ŞTEFAN VELESCU1, EMIL ŞTEFĂNESCU1, OANA ŞEREMET1,
FLORICA NICOLESCU3
Faculty of Pharmacy, University of Medicine and Pharmacy “Carol
Davila”, Bucharest
1Department of Pharmacology and Clinical Pharmacy
2 Department of Biochemistry
3Department of Toxicology
*corresponding author: cristinazbar@yahoo.com
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Abstract:

Due to the fact that depression quantification in laboratory animals is hard to realize, an experimental study was conducted in order to create a model of depression induced by administration of reserpine in white male mice NMRI strain. To this end, three doses of reserpine were tested (0.5mg/kg-bw, 0.75 mg/kg-bw, 1.5 mg/kg-bw), a neurosympatholytic agent which produces catecholamine depletion at central and peripheral level. Depression onset evaluation was performed at 2 moments: after 11 and after 21 days of neurosympatholytic administration, both by classical pharmacological tests and also by determining the cerebral activity of monoamine oxidase (MAO), an enzyme involved in catecholamine catabolism.






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