PREPARATION AND EVALUATION OF
MELOXICAM SOLID DISPERSION BY MELTING
METHOD
ANMAR ADHAM ISSA1,2*, DANIELA MARCHIDAN2 , VICTOR
COJOCARU2, VALENTINA ANUȚA2
1 Department of Pharmacy, Ministry of Health, Iraq
2 University of Medicine and Pharmacy „Carol Davila“, Faculty of
Pharmacy, 6 Traian Vuia, 020956, Bucharest, Romania
*corresponding author: anmaar77@yahoo.com
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Abstract:

Drug formulation as solid dispersion (SD) represents a good method for the
enhancement in solubility of poorly water soluble drugs, as well as for the reduction of ulcergenicity of non-sterodial anti-inflammatory drugs (NSAID). The poorly water soluble Meloxicam (MLX) was used as model drug to prepare solid dispersion. Solid dispersion of MLX was prepared by melting method, using Poloxamer 188 as hydrophilic carrier. A 32 factorial design was used to study the influence of individual and combined effects of 2
factors (drug:polymer ratio and cooling temperature) on the responses.






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