NEW MODIFIED RELEASE TABLETS WITH
PENTOXIFYLLINE BASED ON LIPOPHILIC
MATRIX. NOTE 2. STABILITY STUDY OF THE
ACTIVE SUBSTANCE FROM THE PROPOSED
FORMULATIONS
ELEONORA MIRCIA¹*, SILVIA IMRE2, EMESE SIPOS3, VERONICA
AVRIGEANU¹, GABRIEL HANCU4, BARNA IANTOVICS5,
TEODORA BALACI6
University of Medicine and Pharmacy Târgu-Mureş, Faculty of
Pharmacy, Gh. Marinescu 38, 540139, Târgu-Mureş, Romania
1Organic Chemistry Department
2Drug Analysis Department
3 Pharmaceutical Technology Department
4 Pharmaceutical Chemistry Department
5“Petru Maior” University, Faculty of Science and Letters, Department
of Mathematics and Informatics, Târgu-Mureş, Romania
6University of Medicine and Pharmacy “Carol Davila”, Faculty of
Pharmacy, Pharmaceutical Technology Department, Bucharest, Romania
*corresponding author: nmircia@yahoo.com
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Abstract:

The objective of this study was to test the stability of pentoxifylline in experimentaln formulations based on lipophilic matrix.
In order to achieve this, we studied the influence of heat stress on the stability of the proposed formulations, by keeping the product samples at high temperatures and humidity, in a stability chamber, during periods lasting from one to six months, sampling at different periods of time and then analyzing the test samples.
Experimental results show that all the proposed formulations can be considered stable.

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