PREPARATION AND CHARACTERIZATION OF
NIOSOMES CONTAINING METRONIDAZOLE
CĂTĂLINA DANIELA STAN1, GABRIELA TĂTĂRÎNGĂ2*,
CARMEN GAFIŢANU3, MARIA DRĂGAN1, STERIANA BRAHA3,
MARIA CRISTINA POPESCU4, GABRIELA LISĂ5, ALINA
ŞTEFANACHE6
University of Medicine and Pharmacy “Gr. T. Popa” Iaşi, Faculty of
Pharmacy, 16 Universităţii Street, 700115, Iaşi, Romania
1Department of Drug Industry and Pharmaceutical Biotechnology
2Department of Organic Chemistry
3Department of Pharmaceutical Technology
6Department of General and Inorganic Chemistry
4Department of Physical Chemistry of Polymers, Institute of
Macromolecular Chemistry, “P. Poni” Romanian Academy, 41A Grigore
Ghica Vodă Alley, 700487, Iaşi, Romania
5Department of Physical Chemistry, Faculty of Chemical Engineering
and Environmental Protection,”Gh. Asachi” Technical University, 71D
Mangeron Blv., 700050, Iaşi, Romania
*corresponding author: gtataringa22@yahoo.com
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Abstract:

In the present study the preparation and the characterization of non-ionic
surfactant vesicles (NSV, niosomes) containing metronidazole are described. NSV were prepared by lipid film hydration technique using non-ionic surfactants with cholesterol at 1:2 and 1:1 ratio. At the same time NSV were characterized by melting points, by IR spectroscopy, by TG/DTG (thermogravimetry/derived thermogravimetry) and entrapment efficiency of metronidazole (metronidazole percent concentration). The maximum
metronidazole entrapment was observed in the case of non-ionic surfactant/cholesterol use at 1:1 ratio.

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